Well wire the front RCA sockets of your head unit into your amplifier.
You'l have a postive (+) and negative (-) connection on each speaker, which gets wired into the positive & negative outputs of the amplifier.
One set of outputs will be for the left, and one will be for the right (when you fade the sound on your head unit, you should be able to tell what one does what).
If you've just got the cables, you will need to buy some clips that you can put a screw through (joins the cable to the amp).. i dont know what ones they are but an assorted box of connectors should contain a few!
Im sure someone will be able to advise further on the bits i've missed off (probably all the important stuff)