running rough/ misfire

Hi all

This is my first time here so please be gentle with me,:):)
I have 2006 micra active K12, it has developed a fault which I had diagnosed as a misfire on cylinder 1, I have replaced the ignition coil pack and it seemed OK for about 2 minutes, then it started running rough and miss firing, it then said i had a misfire on cylinder 2, so again I changed it and yet again it cleared and ran fine for a couple of minutes, now its running rough and says misfire on cylinder 4....:(:(:(

Do any of you cleaver people out there have any ideas, i cant just keep changing the coil packs.

Kind regards

Andy ;);)
 
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